Funded Studies: 2005–2009
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Abstracts by year
2009 portfolio summary
The Alzheimer's Association 2009 grants portfolio supports the 84 projects ranked highest by peer reviewers in an extremely competitive field of 815 applications. Key 2009 research themes include:
- 24 percent of projects funded in 2009 explore the molecular mechanisms that contribute to the production of beta-amyloid, the abnormal chemical alterations of tau and the normal functions of related proteins implicated in Alzheimer pathology.
- 26 percent investigate the underlying pathology of Alzheimer's, including the effect of beta-amyloid, mediators of toxicity, the adverse effect of beta-amyloid on cell-to-cell communication, and the effect of Alzheimer's disease on cellular properties and functions that normally protect and maintain neurons in the brain.
- 7 percent examine other factors that may contribute to Alzheimer's disease and other dementias, including blood vessel damage and genetic risk factors.
- 22 percent investigate brain imaging, biomarkers and clinical tools that may result in earlier and more accurate diagnoses, timely interventions and effective disease monitoring.
- 10 percent explore novel treatment strategies and the improvement of clinical trial designs.
- 11 percent study improving care for people with dementia through new technologies, and exploring the values and beliefs of diverse cultures that impact use of health services.
2008 portfolio summary
The Alzheimer's Association 2008 grants portfolio supports the 131 projects ranked highest by peer reviewers in an extremely competitive field of 599 applications. Key 2008 research themes include:
- 14 percent of projects funded in 2008 explore the molecular mechanisms that contribute to the production of beta-amyloid, the abnormal chemical alterations of tau and the normal functions of related proteins implicated in Alzheimer pathology.
- 11 percent investigate the toxic properties of beta-amyloid, mediators of this toxicity and the adverse effect of beta-amyloid on cell-to-cell communication.
- 14 percent study the effect of Alzheimer’s disease on cellular properties and functions that normally protect and maintain neurons in the brain.
- 17 percent examine other factors that may contribute to Alzheimer’s disease, including inflammation, blood vessel damage, nutritional deficits, genetic risk factors and lifestyle factors.
- 11 percent investigate brain imaging, biomarkers and clinical tools that may result in earlier and more accurate diagnoses, timely interventions and effective disease monitoring.
- 18 percent explore novel treatment strategies, including anti-amyloid compounds and nutritional therapies.
- 15 percent study best practices in care for people with dementia living in nursing homes, in assisted-living communities and at home.
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